Orotic Acid Excretion and Arginine Metabolism
نویسندگان
چکیده
منابع مشابه
Orotic acid excretion and arginine metabolism.
The urinary excretion of orotic acid, an intermediate in the pyrimidine biosynthetic pathway, is markedly increased in many inborn errors of the urea cycle and in a number of other disorders involving arginine metabolism. Carbamoyl phosphate, which accumulates within hepatic mitochondria in patients with ornithine transcarbamoylase deficiency, can diffuse to the cytosol and enter the pyrimidine...
متن کاملRefractory megaloblastic anemia associated with excretion of orotic acid.
By CiIAnLI s M. HUGULEY, Jn., JAMES A. BAIN, SHIRLEY L. RIVERS AND ROBERT B. ScoGcINs T HE MAJORITY of anemias associated with a megalohiastic hone marrow respond to vitamin B,2 parenterally. Those which do not respond usually fall into well defined categories of nutritional deficiency, intestinal malahsorption syndromes, pernicious anemia of pregnancy, megaloblastic anemia of infancy or reacti...
متن کاملThe metabolism of ring-labeled orotic acid in man.
Considerable knowledge concerning purine metabolism has been obtained from chemical and isotopic studies of urinary uric acid. Corresponding information in man is lacking for the closely related field of pyrimidine metabolism. The availability of ring-labeled orotic acid as a specific pyrimidine precursor (1), together with the presence of pseudouridine (5-ribosyluracil) and uracil, as specific...
متن کاملThe metabolism of orotic acid in aerobic bacteria.
cocci (Rogers, lW), Laetobaciuus cas& (Chattaway, lW), and Laclobaeiuus bulgcrricus, strain 09 (Wieland et d., 1950; Huff et d., 1950). Further studiea with L. bulgaricw, strain 09 have revealed that ureidosuccinic acid partially replacea that orotic acid ia also a nucleic acid pyrimidine a growth factor for one of the group C streptoprecursor in mammdim tissues. Studiea of orotic acid synthwia...
متن کاملQuinolinic acid excretion and metabolism in man.
In 1946, Rosen e2 al. (1) showed that administration of tryptophan to rats resulted in an additional excretion of nicotinic acid and Nl-methylnicotinamide (Nl-Me). Singal et al. (2) found, in addition to these, increased excretion of another metabolite which could be converted to nicotinic acid by autoclaving in 1 N sulfuric acid solution. Henderson isolated this metabolite from the urine of ra...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2007
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/137.6.1656s